3636. Eprozinol

Nomenclature

CAS number: 32665-36-4
4-(2-Methoxy-2-phenylethyl)-α-phenyl-1-piperazinepropanol; 1-(2-methoxy-2-phenylethyl)-4-(3-hydroxy-3-phenylpropyl)piperazine.
C22H30N2O2; mol wt 354.49.
C 74.54%, H 8.53%, N 7.90%, O 9.03%.

Description and references

Prepn: Saunders, GB 1188505 (1970); to R. Y. Mauvernay, N. Busch, US 3705244 (1972). Pharmacology: Duchene-Marullaz et al., Therapie 26, 155 (1971). Clinical studies: Sors, Dutarte, ibid. 163.

Chemical structure

Derivative

Dihydrochloride.

Nomenclature

CAS number: 27588-43-8
Alecor (Andromaco); Brovel (Lepetit); Eupnéron (Lyocentre).
C22H30N2O2.2HCl; mol wt 427.41.
C 61.82%, H 7.55%, N 6.55%, O 7.49%, Cl 16.59%.

Properties

White crystalline powder, mp 164°. Sol in water and alcohol. LD50 orally in mice: 500 mg/kg (Mauvernay, Busch).

Therapeutic Category

Bronchodilator.

Keywords

Bronchodilator; Ephedrine Derivatives