Nomenclature
CAS number: 3847-29-8
4-
O-β-
d-Galactopyranosyl-
d-gluconic
acid compd with erythromycin (1:1); Erythrocin Lactobionate (Abbott).
Description and references
Semi-synthetic macrolide antibiotic prepd from
erythromycin base and lactobiono-δ-lactone in water-acetone: Hoffhine, US 2761859 (1956 to Abbott); alternate prepn and antibacterial activity: S. K. Dutta,
K. S. Basu, US 4137397 (1979 to Jadavpur Univ.). Pharmacokinetics:
R. L. Parsons et al., J. Int.
Med. Res. 8, suppl. 2, 15 (1980).
Properties
White, amorphous powder, mp 145-150°. Soly in water about 200 mg/ml.
Freely sol in alcohol; slightly sol in ether. pH of a 2% aq soln
6.0-7.5. A 5% stock soln can be prepd with water or glucose soln
but not with NaCl isotonic soln, because NaCl at this concn precipitates
erythromycin base. Lower concns of inorganic salts are compatible.Therapeutic Category
Antibacterial.
Therapeutic Category (Veterinary)
Antibacterial.
Keywords
Antibacterial (Antibiotics); Macrolides