3709. Etafedrine

Nomenclature

CAS number: 7681-79-0
α-[1-(Ethylmethylamino)ethyl]benzenemethanol; l-N-ethylephedrine; l-α-[1-(ethylmethylamino)ethyl]benzyl alcohol; 2-methylethylamino-1-phenyl-1-propanol; Menetryl; Novedrin.
C12H19NO; mol wt 193.29.
C 74.57%, H 9.91%, N 7.25%, O 8.28%.

Description and references

β-Adrenergic agonist. Prepn: Skita, Keil, Ber. 63, 34 (1930); Ueda et al., Pharm. Bull. 3, 465 (1955).

Chemical structure

Derivative

Hydrochloride.

Nomenclature

CAS number: 5591-29-7
Nethamine (HMR).
C12H19NO.HCl; mol wt 229.75.
C 62.73%, H 8.77%, N 6.10%, O 6.96%, Cl 15.43%.

Properties

Crystals from acetone + alcohol, mp 183-184°. One gram dissolves in 1.5 ml water, 8.0 ml alcohol. Aq solns are very stable.

Therapeutic Category

Bronchodilator.

Keywords

β-Adrenergic Agonist; Bronchodilator; Ephedrine Derivatives