3710. Etafenone

Nomenclature

CAS number: 90-54-0
1-[2-[2-(Diethylamino)ethoxy]phenyl]-3-phenyl-1-propanone; 2′-[2-(diethylamino)ethoxy]-3-phenylpropiophenone; o-diethylaminoethoxy-β-phenylpropiophenone; 2′-(β-diethylaminoethoxy)-3-phenylpropiophenone; β-phenyl-o-(diethylaminoethoxy)propiophenone; LG-11457.
C21H27NO2; mol wt 325.44.
C 77.50%, H 8.36%, N 4.30%, O 9.83%.

Description and references

Prepn: G. DiPaco, S. C. Tauro, Ann. Chim. (Rome) 48, 1215 (1958); eidem, DE 1265758 (1968 to Guidotti), C.A. 69, 58950a (1968). Toxicity data: H.-J. Hapke, W. Sterner, Arzneim.-Forsch. 19, 1664 (1969). Series of articles on pharmacology, toxicology, metabolism: ibid. 1664-1681.

Chemical structure

Properties

Liquid, bp30 264-268°.

Derivative

Hydrochloride.

Nomenclature

Hetaphenone; Asamedol (Maruko); Baxacor (Mack, Illert.); Corodilan (Meiji); Dialicor (Kissei); Pagano-Cor (Helopharm); Relicor.
C21H27NO2.HCl; mol wt 361.91.
C 69.69%, H 7.80%, N 3.87%, O 8.84%, Cl 9.80%.

Properties

Crystals, mp 129-130°. LD50 in rats (mg/kg): 716 orally; 20.8 i.v. (Hapke, Sterne).

Therapeutic Category

Vasodilator (coronary).

Keywords

Calcium Channel Blocker; Vasodilator (Coronary)