3711. Etamiphyllin

Nomenclature

CAS number: 314-35-2
7-[2-(Diethylamino)ethyl]-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione; 7-(2-diethylaminoethyl)theophylline; 7-(2-diethylaminoethyl)-1,3-dimethylxanthine; 1,3-dimethyl-7-(2-diethylaminoethyl)xanthine; dietamiphylline; etamiphylline.
C13H21N5O2; mol wt 279.34.
C 55.90%, H 7.58%, N 25.07%, O 11.46%.

Description and references

Prepn: Quevauviller et al., Bull. Soc. Chim. Biol. 31, 532 (1946); Moussalli et al., GB 669070 (1952); Klosa, Arch. Pharm. 288, 301 (1955). Toxicity data on combinations: Baettig, Arzneim.-Forsch. 21, 354 (1971). Pharmacokinetics, metabolism, and urinary determn in camels: M. Elghazali et al., J. Vet. Pharmacol. Ther. 25, 43 (2002); GC/MS and LC/MS determn in greyhound urine: M. C. Dumasia, P. Teale, J. Pharm. Biomed. Anal. 36, 1085 (2005).

Chemical structure

Properties

Waxy solid, mp 75°. Very sol in water, acetone; slightly sol in ethanol, ether.

Derivative

Hydrochloride.

Nomenclature

CAS number: 17140-68-0
Solufilina (Merck KGaA).
C13H21N5O2.HCl; mol wt 315.80.
C 49.44%, H 7.02%, N 22.18%, O 10.13%, Cl 11.23%.

Properties

Crystals, mp 239-241°. Very sol in water, forms stable neutral soln.

Derivative

Camphorsulfonate.

Nomenclature

CAS number: 19326-29-5
Etamiphylline camsylate; Millophyline (Arnolds).
C23H37N5O6S; mol wt 511.63.
C 53.99%, H 7.29%, N 13.69%, O 18.76%, S 6.27%.

Properties

Crystals, mp 174°.

Therapeutic Category

Bronchodilator.

Therapeutic Category (Veterinary)

Bronchodilator.

Keywords

Bronchodilator; Xanthine Derivatives