3722. Ethamsylate

Nomenclature

CAS number: 2624-44-4
2,5-Dihydroxybenzenesulfonic acid compd with N-ethylethanamine; diethylammonium 2,5-dihydroxybenzenesulfonate; 1-hydroxy-4-oxo-2,5-cyclohexadiene-1-sulfonic acid compd with diethylamine; diethylammonium cyclohexadien-4-ol-1-one-4-sulfonate; cyclonamine; etamsylate; MD-141; E-141; Aglumin; Altodor (Synthelabo); Biosinon (Farmakhim); Dicynene (Lorex); Dicynone (OM).
C10H17NO5S; mol wt 263.31.
C 45.61%, H 6.51%, N 5.32%, O 30.38%, S 12.18%.

Description and references

Prepn: GB 895709 (1962 to Labs. OM); ES 279303 (1962 to Labs. Esteve), C.A. 60, 1652g (1964). Pharmacology: Demars, Med. Exp. 4, 173 (1961); Huguet et al., Therapie 24, 429 (1969). Toxicity: Esteve et al., Therapie 15, 110 (1960).

Chemical structure

Properties

Crystals from ethanol, mp 125°. LD50 i.v. in mice, rats: 800, 1350 mg/kg (Esteve).

Therapeutic Category

Hemostatic.

Keywords

Hemostatic