3721. Ethamivan

Nomenclature

CAS number: 304-84-7
N,N-Diethyl-4-hydroxy-3-methoxybenzamide; N,N-diethylvanillamide; vanillic acid diethylamide; vanillic diethylamide; Vandid (3M Pharma); Cardiovanil; Emivan (USV).
C12H17NO3; mol wt 223.27.
C 64.55%, H 7.67%, N 6.27%, O 21.50%.

Description and references

Prepd by dissolving vanillic acid O-acyl amide in NaOH and neutralizing with CO2 or acid: Kratzl, Kvasnicka, Monatsh. Chem. 83, 18 (1952); by refluxing a mixture of vanillic acid, P2O5 and powdered glass in xylene and treating with K2CO3: eidem, US 2641612 (1953 to Oesterr. Stickstoffwerke). Toxicity study: Caujolle et al., Compt. Rend. 243, 609 (1956).

Chemical structure

Properties

Needles from ligroin, mp 95-95.5°. LD50 i.p. in rats: 28 mg/kg (Caujolle).

Therapeutic Category

CNS stimulant; respiratory stimulant.

Keywords

CNS Stimulant; Respiratory Stimulant