3733. Ethinamate
Nomenclature
CAS number: 126-52-3
1-Ethynylcyclohexanol 1-carbamate; carbamic acid 1-ethynylcyclohexyl ester; ethynylcyclohexyl carbamate; Valamin (Schering AG); Valmid (Lilly); Valmidate. C9H13NO2; mol wt 167.21.
C 64.65%, H 7.84%, N 8.38%, O 19.14%.
Description and references
Prepn: K. Junkmann, H. Pfeiffer, US 2816910 (1957 to Schering, AG).
Properties
Needles from cyclohexane, mp 96-98°. bp3 118-122°. Shows no optical activity. nD21.5 1.4441 (20% in propylene glycol). Soly at 25° in water 0.25%, ethanol 35.0%, hexane 2.0%, sesame oil 0.7%, 1,2-propylene glycol 22%. Lowers the surface tension in satd aq soln at 22° by 21%. Partition coefficient (oil/water): 1.48.Note
This is a controlled substance (depressant): 21 CFR, 1308.14.Therapeutic Category
Sedative; hypnotic.
Keywords
Sedative/Hypnotic; Carbamates