3748. Ethosuximide

Nomenclature

CAS number: 77-67-8
3-Ethyl-3-methyl-2,5-pyrrolidinedione; 2-ethyl-2-methylsuccinimide; α-ethyl-α-methylsuccinimide; 3-methyl-3-ethylpyrrolidine-2,5-dione; Atysmal (Schaefer); Capitus (Berk); Emeside (L.A.B.); Epileo Petitmal (Eisai); Ethymal; Mesentol; Pemal (Benzon); Peptinimid (Iromedica); Petinimid; Petnidan (Desitin); Pyknolepsinum (Rhein-Pharma); Simatin (Geistlich); Succimal (Clin-Comar-Byla); Suxilep; Suximal; Suxinutin (Parke-Davis); Zarontin (Parke-Davis).
C7H11NO2; mol wt 141.17.
C 59.56%, H 7.85%, N 9.92%, O 22.67%.

Description and references

Prepn: Sircar, J. Chem. Soc. 1927, 1252. Acute toxicity data: H. Najer et al., Bull. Soc. Chim. Fr. 3, 1119 (1966). Comparative clinical trial with valproic acid in epilepsy: S. Sato et al., Neurology 32, 157 (1982). Brief review: S. J. Wallace, Neurol. Clin. 4, 601 (1986).

Chemical structure

Properties

Crystals from acetone + ether, mp 64-65°. Freely sol in water. LD50 in mice (g/kg): 1.65 i.p.; 1.75 orally (Najer).

Therapeutic Category

Anticonvulsant.

Keywords

Anticonvulsant