3821. Ethyl Loflazepate

Nomenclature

CAS number: 29177-84-2
7-Chloro-5-(2-fluorophenyl)-2,3-dihydro-2-oxo-1H-1,4-benzodiazepine-3-carboxylic acid ethyl ester; ethyl 7-chloro-5-(o-fluorophenyl)-2,3-dihydro-2-oxo-1H-1,4-benzodiazepine-3-carboxylate; CM-6912; Meilax (Meiji Seika); Victan (Sanofi Winthrop).
C18H14ClFN2O3; mol wt 360.77.
C 59.93%, H 3.91%, Cl 9.83%, F 5.27%, N 7.76%, O 13.30%.

Description and references

Benzodiazepine tranquilizer. Prepn: J. Hellerbach et al., DE 2001276; eidem, US 3657223 (1970, 1972 both to Hoffmann-La Roche). Analysis in plasma and urine: W. Cantreels, J. R. Jeanniot, Biomed. Mass Spectrom. 7, 565 (1980). GC analysis of metabolites: J. P. Cano, J. Chromatogr. 226, 413 (1981). Toxicologic evaluation: G. Mozue et al., Int. J. Clin. Pharmacol. Ther. Toxicol. 19, 453 (1981).

Chemical structure

Properties

Crystals from ether, mp 193-194°.

Note

This is a controlled substance (depressant): 21 CFR, 1308.14.

Therapeutic Category

Anxiolytic.

Keywords

Anxiolytic; Benzodiazepine Derivatives