3852. Ethylstibamine

Nomenclature

CAS number: 1338-98-3
Bayer 693; Neostibosan; Stibosamine; Astaril.

Description and references

A complex of p-aminobenzenestibonic acid (present largely as a tetramer), p-acetylaminobenzenestibonic acid (present largely as a dimer), antimonic acid and diethylamine in the approx molar ratio of 1:2:1:3. Contains 41 to 44% organic pentavalent antimony (the acetyl content is between 6 and 7%). The manuf requires special care since the compd is both a colloid and a molecular addition compd and slight variations affect its toxicity greatly: Schmidt, Angew. Chem. 43, 963 (1930); US 1988632, C.A. 29, 1586 (1935).

Properties

Light-yellow to yellowish-brown powder. Freely sol in water forming neutral, colloidal solns. The pH of a 5% soln is between 6.5 and 7.6. A 25% soln is approx isotonic. Solns for injection should be prepd immediately before use with sterile distilled water, as they are unstable on heating or standing.

Therapeutic Category

Antiprotozoal (Leishmania).

Keywords

Antiprotozoal (Leishmania)