3865. Etilefrin

Nomenclature

CAS number: 709-55-7
α-[(Ethylamino)methyl]-3-hydroxybenzenemethanol; α-[(ethylamino)methyl]-m-hydroxybenzyl alcohol; m-hydroxy-α-(ethylaminomethyl)benzyl alcohol; α-(m-hydroxyphenyl)-β-(ethylamino)ethanol; ethylphenylephrine; etiladrianol.
C10H15NO2; mol wt 181.23.
C 66.27%, H 8.34%, N 7.73%, O 17.66%.

Description and references

Sympathomimetic amine. Prepn: T. Goto, J. Pharm. Soc. Jpn. 74, 318 (1954), C.A. 49, 3960 (1955); ES 273595 (1962 to Labs. Fher S.A.), C.A. 60, 1649e (1964). Clinical pharmacology: A. J. Coleman et al., Eur. J. Clin. Pharmacol. 8, 41 (1975). Clinical pharmacokinetics and disposition: J. H. Hengstmann et al., ibid. 9, 179 (1975). HPLC determn in plasma: K. Kojima et al., J. Chromatogr. 525, 210 (1990). Clinical trial in arterial hypotension: T. Taivainen, Acta Anaesthesiol. Scand. 35, 164 (1991); in neurocardiogenic syncope: F. Ammirati et al., Am. J. Cardiol. 86, 472 (2000).

Chemical structure

Properties

Crystals, mp 147-148°.

Derivative

Hydrochloride.

Nomenclature

CAS number: 534-87-2
Cardanat (Temmler); Circupon (Gepepharm); Effontil (Boehringer, Ing.); Effortil (Boehringer, Ing.); Efortil (Boehringer, Ing.); Kertasin (Merck KGaA); Thomasin (Apogepha).
C10H15NO2.HCl; mol wt 217.69.
C 55.17%, H 7.41%, N 6.43%, O 14.70%, Cl 16.29%.

Properties

Crystals, mp 121°. Bitter taste. Freely sol in water; sol in alcohol. Practically insol in chloroform.

Therapeutic Category

Antihypotensive.

Therapeutic Category (Veterinary)

Antihypotensive.

Keywords

Antihypotensive