3870. Etiprednol Dicloacetate

Nomenclature

CAS number: 199331-40-3
(11β,17α)-17-[(Dichloroacetyl)oxy]-11-hydroxy-3-oxoandrosta-1,4-diene-17-carboxylic acid ethyl ester; ethyl 17α-dichloroacetoxy-11β-hydroxyandrosta-1,4-diene-3-one-17β-carboxylate; BNP-166; Cronaze (Ivax); Respicort (Ivax).
C24H30Cl2O6; mol wt 485.40.
C 59.39%, H 6.23%, Cl 14.61%, O 19.78%.

Description and references

A so-called "soft" corticosteroid; designed to undergo predictable metabolism to an inactive compound. Prepn: N. S. Bodor, M. K. Baumeister, WO 9742214; eidem, US 5981517 (1997, 1999 both to Soft Drugs, Inc.); A. Csanádi et al., Pharmazie 59, 349 (2004). Toxicology and safety in animals: A. Miklós et al., ibid. 57, 142 (2002). Pharmacology in animal model of asthma: I. Kurucz et al., J. Pharmacol. Exp. Ther. 307, 83 (2003).

Chemical structure

Properties

White crystalline powder from ethyl acetate, mp 201-202.5°.

Therapeutic Category

Glucocorticoid; in treatment of Crohn's disease.

Keywords

Glucocorticoid