3882. Etomidoline

Nomenclature

CAS number: 21590-92-1
2-Ethyl-2,3-dihydro-3-[[4-[2-(1-piperidinyl)ethoxy]phenyl]amino]-1H-isoindol-1-one; 2-ethyl-3-(β-piperidino-p-phenetidino)phthalimidine; K-2680; Smedolin (Yamanouchi).
C23H29N3O2; mol wt 379.50.
C 72.79%, H 7.70%, N 11.07%, O 8.43%.

Description and references

Anticholinergic antispasmodic. Prepn: N. Giraldi, V. Mariotti, ZA 6705704; eidem, US 3624206 (1968, 1971 both to Erba). Quantitative evaluation in humans: G. Sacchetti et al., Farmaco Ed. Prat. 27, 708 (1972). Spasmolytic properties: M. Takeda, Oyo Yakuri 7, 903 (1973), C.A. 80, 66678 (1974). Pharmacology: M. Takeda et al., ibid. 1073, C.A. 81, 33285 (1974); T. Mukai et al., Jpn. J. Pharmacol. 31, 147 (1981), C.A. 95, 18068 (1981).

Chemical structure

Properties

Crystals from ligroin, mp 106-107°. LD50 in mice (mg/kg): 176 orally; 44.8 i.v. (Giraldi, Mariotti, 1971).

Therapeutic Category

Antispasmodic.

Keywords

Antispasmodic