3889. Etoxadrol

Nomenclature

CAS number: 28189-85-7
(2S)-2-[(2S,4S)]-2-(2-Ethyl-2-phenyl-1,3-dioxolan-4-yl)piperidine; (+)-2-(2-Ethyl-2-phenyl-1,3-dioxolan-4-yl)piperidine; 2-ethyl-2-phenyl-4-(2-piperidyl)-1,3-dioxolane.
C16H23NO2; mol wt 261.36.
C 73.53%, H 8.87%, N 5.36%, O 12.24%.

Description and references

Prepn of dl-form: Hardie et al., J. Med. Chem. 9, 127 (1966); Hardie, Halverstadt, US 3262938 (1966 to Cutter Labs). Resolution of the α-racemates: Allen et al., DE 2001616 (1970 to Cutter Labs), C.A. 74, 13129b (1971). Pharmacological studies: Traber et al., J. Pharmacol. Exp. Ther. 175, 395 (1970); Hidalgo et al., Anesth. Analg. 50, 231 (1971); Kelly et al., ibid. 262.

Chemical structure

Derivative

(+)-Hydrochloride.

Nomenclature

CAS number: 23239-37-4
CL-1848C; Thoxan (Cutter).
C16H23NO2.HCl; mol wt 297.82.
C 64.53%, H 8.12%, N 4.70%, O 10.74%, Cl 11.90%.

Properties

Crystals from isopropanol, mp 221.5-222°. [α]D25 +16.63°.

Therapeutic Category

Anesthetic (intravenous).

Keywords

Anesthetic (Intravenous)