3960. Fenbendazole

Nomenclature

CAS number: 43210-67-9
[5-(Phenylthio)-1H-benzimidazol-2-yl]carbamic acid methyl ester; 5-(phenylthio)-2-benzimidazolecarbamic acid methyl ester; methyl 5-(phenylthio)-2-benzimidazolecarbamate; HOE-881v; Panacur (Intervet).
C15H13N3O2S; mol wt 299.35.
C 60.18%, H 4.38%, N 14.04%, O 10.69%, S 10.71%.

Description and references

Prepn: H. Loewe et al., DE 2164690; eidem, US 3954791 (1973, 1976 both to Hoechst); C. Baeder et al., Experientia 30, 753 (1974). Efficacy vs gastrointestinal nematodes in swine: Enigk et al., Dtsch. Tieraerztl. Wochenschr. 81, 177 (1974).

Chemical structure

Properties

Light brownish-gray, odorless, tasteless crystalline powder, mp 233° (dec). Insol in water; insol or only very slightly sol in the usual solvents. Freely sol in DMSO.

Therapeutic Category (Veterinary)

Anthelmintic (Nematodes).