3965. Fenbutrazate

Nomenclature

CAS number: 4378-36-3
α-Ethylbenzeneacetic acid 2-(3-methyl-2-phenyl-4-morpholinyl)ethyl ester; 2-phenylbutyric acid 2-(3-methyl-2-phenylmorpholino)ethyl ester; 2-(3-methyl-2-phenylmorpholino)ethyl 2-phenylbutyrate; phenbutrazate.
C23H29NO3; mol wt 367.48.
C 75.17%, H 7.95%, N 3.81%, O 13.06%.

Description and references

Prepn: H. Siemer, O. Hengen, US 3018222 (1962 to Ravensberg). Physical properties and pharmacology: O. Hengen, H. Siemer, Arzneim.-Forsch. 5, 526 (1955).

Chemical structure

Properties

Honey colored, viscous oil, bp0.05 235-240°. Sol in methanol with neutral reaction.

Derivative

Hydrochloride.

Nomenclature

CAS number: 6474-85-7
R-381.
C23H29NO3.HCl; mol wt 403.94.
C 68.39%, H 7.49%, N 3.47%, O 11.88%, Cl 8.78%.

Properties

Crystals, mp 154°. Slightly sol in water; sol in ethanol, acetone. Practically insol in ether, benzene. LD50 in mice (mg/kg): 3200 orally; 2800 s.c. (Hengen, Seimer).

Derivative

Hydrochloride mixture with phenmetrazine theoclate.

Nomenclature

CAS number: 8004-38-4
Cafilon (Ravensberg); Filon (Berk).

Therapeutic Category

Anorexic.

Keywords

Anorexic