3971. Fendosal

Nomenclature

CAS number: 53597-27-6
5-(4,5-Dihydro-2-phenyl-3H-benz[e]indol-3-yl)-2-hydroxybenzoic acid; 5-(4,5-dihydro-2-phenyl-3H-benz[e]indol-3-yl)salicylic acid; 3-(3-carboxy-4-hydroxyphenyl)-2-phenyl-4,5-dihydro-3H-benz[e]indole; HP-129; P-71-0129; Alnovin (Hoechst).
C25H19NO3; mol wt 381.42.
C 78.72%, H 5.02%, N 3.67%, O 12.58%.

Description and references

Prepn: R. C. Allen, B. Anderson, DE 2407671; eidem, US 3878225 (1974, 1975 both to Hoechst); V. B. Anderson et al., J. Med. Chem. 19, 318 (1976). Pharmacology: H. B. Lassman et al., Agents Actions 8, 209 (1978). Clinical study: S. S. Bloomfield et al., Clin. Pharmacol. Ther. 23, 390 (1978).

Chemical structure

Properties

Crystals from acetic acid, mp 223-225° (dec). LD50 in mice, rats, rabbits (mg/kg): 740, 450, 560 orally; in mice (mg/kg): 510 i.p. (Lassman).

Therapeutic Category

Anti-inflammatory.

Keywords

Anti-inflammatory (Nonsteroidal); Salicylic Acid Derivatives