3972. Fenethylline

Nomenclature

CAS number: 3736-08-1
3,7-Dihydro-1,3-dimethyl-7-[2-[(1-methyl-2-phenylethyl)amino]ethyl]-1H-purine-2,6-dione; 7-[2-[(α-methylphenethyl)amino]ethyl]theophylline; 7-[β-(α-methyl-β-phenylethylamino)ethyl]theophylline; 7-(phenylisopropylaminoethyl)theophylline; 7-(3-phenyl-2-propylaminoethyl)theophylline; theophyllineethylamphetamine.
C18H23N5O2; mol wt 341.41.
C 63.32%, H 6.79%, N 20.51%, O 9.37%.

Description and references

Prepn from 7-(β-chloroethyl)theophylline and amphetamine: Kholstaedt, Klinger, DE 1123329 (1962 to Degussa), C.A. 57, 5933c (1962). Metabolism in man: T. Ellison et al., Eur. J. Pharmacol. 13, 123 (1970).

Chemical structure

Derivative

Hydrochloride.

Nomenclature

CAS number: 1892-80-4
H-814; Captagon (Viatris).
C18H23N5O2.HCl; mol wt 377.87.
C 57.21%, H 6.40%, N 18.53%, O 8.47%, Cl 9.38%.

Properties

Crystals, two different modifications, mp 227-229° and mp 237-239°.

Derivative

d-Form hydrochloride.

Properties

Crystals, mp 246-247°.

Derivative

l-Form hydrochloride.

Properties

Crystals, mp 246-247°.

Note

This is a controlled substance (stimulant): 21 CFR, 1308.11.

Therapeutic Category

CNS stimulant.

Keywords

CNS Stimulant