3982. Fenoverine

Nomenclature

CAS number: 37561-27-6
10-[[4-(1,3-Benzodioxol-5-ylmethyl)-1-piperazinyl]acetyl]-10H-phenothiazine; 10-[4-(3,4-dioxymethylenebenzyl)-1-piperazinylacetyl]phenothiazine; 10-[(4-piperonyl-1-piperazinyl)acetyl]phenothiazine; Spasmopriv (Paillusseau).
C26H25N3O3S; mol wt 459.56.
C 67.95%, H 5.48%, N 9.14%, O 10.44%, S 6.98%.

Description and references

Piperonylpiperazine derivative with spasmolytic activity. Prepn: A. Buzas, R. Pierre, FR 2092639 (1972), C.A. 77, 140143p (1972). Pharmacology, clinical studies in gastrointestinal disorders, dysmenorrhea: R. Pierre, R. Roustan, Med. Interne 15, 49 (1980). In treatment of colon dysfunction: Claudon, Rev. Fr. Gastro-Enterol. 198, 31 (1984).

Chemical structure

Properties

Crystals from isopropyl ether, mp 141-142°. LD50 in mice (g/kg): ≈1.50 orally, ≈2.50 i.p. (Buzas, Pierre).

Therapeutic Category

Antispasmodic.

Keywords

Antispasmodic