3994. Fenproporex

Nomenclature

CAS number: 15686-61-0
3-[(1-Methyl-2-phenylethyl)amino]propanenitrile; (±)-3-[(α-methylphenethyl)amino]propionitrile; (±)-N-2-cyanoethylamphetamine.
C12H16N2; mol wt 188.27.
C 76.55%, H 8.57%, N 14.88%.

Description and references

Deriv of amphetamine, q.v. Prepn: FR M4364; P. Pohrbach, J. Blum, US 3485924 (1966, 1969 both to Bottu). Pharmacological studies: B. M. Beecham et al., J. Pharm. Pharmacol. 23, 140 (1971); A. H. Beckett et al., ibid. 24, 194 (1972). Peripheral effects in human and rat adipose tissue: M. Dubost et al., Br. J. Pharmacol. 58, 436P (1976). Chromatographic identification of amphetamine in urine of patients treated with fenproporex: R. B. Sznelvar, Eur. J. Toxicol. Environ. Hyg. 8, 5 (1975). Clinical trial: G. Hertel, W. Fallot-Burghardt, Fortschr. Med. 96, 2380 (1978).

Chemical structure

Properties

Liquid, bp2 126-127°.

Derivative

Hydrochloride.

Nomenclature

CAS number: 18305-29-8
Gacilin (Andromaco); Solvolip (Knoll).
C12H16N2.HCl; mol wt 224.73.
C 64.13%, H 7.62%, N 12.47%, Cl 15.78%.

Properties

White, cryst, odorless powder from abs ethanol, mp 146°. Bitter taste. Sol in water, 95% ethanol.

Note

This is a controlled substance (stimulant): 21 CFR, 1308.14.

Therapeutic Category

Anorexic.

Keywords

Anorexic