3999. Fenspiride

Nomenclature

CAS number: 5053-06-5
8-(2-Phenylethyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one; decaspiride; DESP.
C15H20N2O2; mol wt 260.33.
C 69.20%, H 7.74%, N 10.76%, O 12.29%.

Description and references

α-Adrenergic blocker. Prepn: NL 6504602; Regnier et al., US 3399192 (1965 and 1968, both to Sci. Union et Cie-Soc. Franc. Recherche Méd.). Pharmacology: LeDouarec et al., Arzneim.-Forsch. 19, 1263 (1969); Duhault et al., ibid. 22, 1947 (1972).

Chemical structure

Derivative

Hydrochloride.

Nomenclature

CAS number: 5053-08-7
NAT-333; NDR-5998A; Decaspir (Pulitzer); Fluiden (Lafare); Pneumorel (Stroder); Respiride (Schiapparelli); Tegencia (Elmu); Viarespan (Servier).
C15H20N2O2.HCl; mol wt 296.79.
C 60.70%, H 7.13%, N 9.44%, O 10.78%, Cl 11.95%.

Properties

Crystals decomp 232-233°. Soluble in water. LD50 i.v. in mice: 106 mg/kg; orally in rats: 437 mg/kg (LeDouarec).

Therapeutic Category

Bronchodilator.

Keywords

α-Adrenergic Blocker; Bronchodilator