4047. Ferrous Gluconate

Nomenclature

CAS number: 299-29-6
Bis(d-gluconato-O1,O2)-iron; Fergon (Miles); Ferlucon; Ferronicum (Sandoz); Iromon (Gador); Irox; Nionate (Nion).
C12H22FeO14; mol wt 446.14.
C 32.31%, H 4.97%, Fe 12.52%, O 50.21%.
Fe[HOCH2(CHOH)4CO2]2.

Description and references

Prepd from Ba gluconate and FeSO4. Prepn of isotonic solns: Hammarlund, Pharm. Acta Helv. 35, 593 (1960). Toxicity study: Hoppe et al., Am. J. Med. Sci. 230, 491 (1955).

Derivative

Dihydrate.

Properties

Yellowish-gray or pale greenish-yellow powder. Slight odor of caramel. Acid to litmus. Sol in water. Practically insol in alcohol. Aq solns are stabilized by the addition of glucose. Extensive stability studies on aq solns: Johnson, Thomas, J. Pharm. Pharmacol. 6, 1037 (1954). LD50 in mice: 114 mg/kg i.v.; 3.7 g/kg orally (Hoppe).

Use

As coloring and flavoring in foods.

Therapeutic Category

Hematinic.

Keywords

Hematinic