4084. Fipexide

Nomenclature

CAS number: 34161-24-5
1-(1,3-Benzodioxol-5-ylmethyl)-4-[(4-chlorophenoxy)acetyl]piperazine; 1-[(p-chlorophenoxy)acetyl]-4-piperonylpiperazine; 1-[2-(4-chlorophenoxy)acetyl]-4-(3,4-methylenedioxybenzyl)piperazine.
C20H21ClN2O4; mol wt 388.84.
C 61.78%, H 5.44%, Cl 9.12%, N 7.20%, O 16.46%.

Description and references

Prepn of hydrochloride: A. Buzas, R. Pierre, FR M7524 (1970 to Lab Bouchard), C.A. 75, 112865r (1971). Manufacturing process: G. P. Gardini et al., US 4225714 (1980 to Farmaceutici Geymon.). Improved prepn: G. P. Gardini et al., Synth. Commun. 12, 887 (1982). Determn by TLC: G. Musumarra et al., J. Chromatogr. 350, 151 (1985). Toxicology and pharmacology: G. David et al., Acta Ther. 11, 387 (1985). Clinical trial in the elderly: B. Bompani, G. Scali, Curr. Med. Res. Opin. 10, 99 (1986).

Chemical structure

Derivative

Hydrochloride.

Nomenclature

CAS number: 34161-23-4
BP-662; Attentil (Ravizza); Vigilor (Bouchard).
C20H21ClN2O4.HCl; mol wt 425.31.
C 56.48%, H 5.21%, Cl 16.67%, N 6.59%, O 15.05%.

Properties

Crystals from ethanol, mp 230-232°. LD50 in Swiss mice, Sprague-Dawley rats, Wistar rats (mg/kg): 4150, 4482, 7000 orally; 499, 537, 450 i.p. (David).

Therapeutic Category

Nootropic.

Keywords

Nootropic