4113. Fluacizine

Nomenclature

CAS number: 30223-48-4
10-[3-(Diethylamino)-1-oxopropyl]-2-(trifluoromethyl)-10H-phenothiazine; 10-(N,N-diethyl-β-alanyl)-2-(trifluoromethyl)phenothiazine; fluoracisine; fluoracizine; ftoracizine; Phtorazisin (Medexport).
C20H21F3N2OS; mol wt 394.45.
C 60.90%, H 5.37%, F 14.45%, N 7.10%, O 4.06%, S 8.13%.

Description and references

Phenothiazine derivative with psychotropic activity. Prepn: Y. I. Vikhlyaev et al., SU 360342 (1972), C.A. 78, 97683w (1973); of hydrochloride: S. V. Zhuravlev et al., GB 1191800 (1970), C.A. 73, 25493h (1970); Y. I. Vikhlyaev et al., FR 2035748 (1971), C.A. 75, 140872j (1971); eidem, DE 1805659 (1979), C.A. 75, 49101w (1971). Use as antidepressant: eidem, SU 356992 (1972), C.A. 78, 75888q (1973) (all to Inst. Pharmacol. Chemother., Acad. Med. Sci., USSR). Mass spectrum: S. Morosawa et al., Org. Mass Spectrom. 17, 309 (1982). Effect on drug metabolism: V. Avakumov et al., Biochem. Pharmacol. 27, 2177 (1978). Pharmacokinetics in animals, man: V. P. Zherdev et al., Farmakol. Toksikol. (Moscow) 45, 83 (1982).

Chemical structure

Derivative

Hydrochloride.

Nomenclature

Fluoracyzine; toracizin.
C20H21F3N2OS.HCl; mol wt 430.91.
C 55.75%, H 5.15%, F 13.23%, N 6.50%, O 3.71%, S 7.44%, Cl 8.23%.

Properties

White cryst powder, mp 163-165°. Sol in water, warm alcohols.

Therapeutic Category

Antidepressant.

Keywords

Antidepressant; Tricyclics