4114. Fluanisone

Nomenclature

CAS number: 1480-19-9
1-(4-Fluorophenyl)-4-[4-(2-methoxyphenyl)-1-piperazinyl]-1-butanone; 4′-fluoro-4-[4-(o-methoxyphenyl)-1-piperazinyl]butyrophenone; haloanisone; R-2028; Sedalande (J & J).
C21H25FN2O2; mol wt 356.43.
C 70.76%, H 7.07%, F 5.33%, N 7.86%, O 8.98%.

Description and references

Prepn: Janssen, US 2997472 (1961). Determn in human plasma: M. P. Quaglio, A. M. Bellini, Farmaco Ed. Prat. 36, 204 (1981). Comparison between biochemical and behavioral effects: G. B. Fregnan, R. Porta, Arzneim.-Forsch. 31, 70 (1981). Toxicity study: C. Cascio et al., Farmaco Ed. Sci. 35, 605 (1980).

Chemical structure

Properties

Crystals, mp 67.5-68.5°. Sol in chloroform; sparingly sol in methanol; slightly sol in ether. Practically insol in water. LD50 i.p. in mice: 200 mg/kg (Cascio).

Derivative

Hydrochloride.

Properties

mp 205-205.5°.

Therapeutic Category

Antipsychotic.

Keywords

Antipsychotic; Butyrophenones