4136. Flumecinol

Nomenclature

CAS number: 56430-99-0
α-Ethyl-α-phenyl-3-(trifluoromethyl)benzenemethanol; α-ethyl-3-(trifluoromethyl)benzhydrol; RGH-3332; Zixoryn (Gedeon Richter); Zyxorin (Gedeon Richter).
C16H15F3O; mol wt 280.28.
C 68.56%, H 5.39%, F 20.34%, O 5.71%.

Description and references

Hepatic microsomal enzyme inducer. Prepn: E. Toth et al., DE 2438399; eidem, US 4039589 (1975, 1977 both to Gedeon-Richter). GC determn in biological fluids: I. Klebovich, L. Vereczkey, J. Chromatogr. 221, 403 (1980). Toxicity study: M. Ledniczky et al., Arzneim.-Forsch. 28, 669 (1978). Series of articles on metabolism, CNS effects, enzyme induction, pharmacological properties: ibid. 663-679.

Chemical structure

Properties

Oil, bp0.03 106-108°. uv max (ethanol): 259, 265, 271 nm. LD50 orally in adult rats: 2235 mg/kg (Ledniczky).

Therapeutic Category

Enzyme inducer (hepatic).

Keywords

Enzyme Inducer (Hepatic)