4137. Flumequine

Nomenclature

CAS number: 42835-25-6
9-Fluoro-6,7-dihydro-5-methyl-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid; R-802; Apurone (3M Pharma); Fantacin (Kyowa Hakko).
C14H12FNO3; mol wt 261.25.
C 64.36%, H 4.63%, F 7.27%, N 5.36%, O 18.37%.

Description and references

Fluorinated quinolone antibacterial. Prepn: J. F. Gerster, DE 2264163; idem, US 3896131 (1973, 1975 both to Riker). In vitro study: G. Stilwell et al., Antimicrob. Agents Chemother. 7, 483 (1975). Bioevaluation: S. R. Rohlfing et al., J. Antimicrob. Chemother. 3, 615 (1977). Activity vs E. coli: D. Greenwood, Antimicrob. Agents Chemother. 13, 479 (1978).

Chemical structure

Properties

White microcrystalline powder, mp 253-255°. Sol in alkaline solns and alcohol. Insol in water.

Therapeutic Category

Antibacterial.

Therapeutic Category (Veterinary)

Antibacterial.

Keywords

Antibacterial (Synthetic); Quinolones and Analogs