4192. Fluprednisolone

Nomenclature

CAS number: 53-34-9
(6α,11β)-6-Fluoro-11,17,21-trihydroxypregna-1,4-diene-3,20-dione; 6α-fluoroprednisolone; 6α-fluoro-1,4-pregnadiene-11β,17α,21-triol-3,20-dione; 6α-fluoro-1-dehydrohydrocortisone; U-7800; NSC-47439; Etadrol (Farmitalia).
C21H27FO5; mol wt 378.43.
C 66.65%, H 7.19%, F 5.02%, O 21.14%.

Description and references

Prepn: Hogg, Spero, US 2841600 (1958 to Upjohn); Batres et al., DE 1079042 (1960 to Syntex); Lettré, Hotz, DE 1088953 (1960 to Bayer).

Chemical structure

Properties

Crystals, mp 208-213°. [α]D +92°.

Derivative

21-Acetate.
C23H29FO6; mol wt 420.47.
C 65.70%, H 6.95%, F 4.52%, O 22.83%.

Properties

Crystals, mp 235-238°.

Therapeutic Category

Glucocorticoid; anti-inflammatory.

Therapeutic Category (Veterinary)

Anti-inflammatory.

Keywords

Glucocorticoid