4193. Fluproquazone
Nomenclature
CAS number: 40507-23-1
4-(4-Fluorophenyl)-7-methyl-1-(1-methylethyl)-2(1H)-quinazolinone; 1-isopropyl-7-methyl-4-(p-fluorophenyl)-2(1H)-quinazolinone; RF-46-790; Tormosyl. C18H17FN2O; mol wt 296.34.
C 72.95%, H 5.78%, F 6.41%, N 9.45%, O 5.40%.
Description and references
Non-steroidal anti-inflammatory drug (NSAID). Fluoro analog of proquazone, q.v. Prepn: G. E. Hardtmann et al., DE 2230393 (1973 to Sandoz), C.A. 78, 111363a (1973); G. E. Hardtmann, US 3937705 (1976 to Sandoz). Analgesic effect: U. Herrmann et al., Clin. Pharmacol. Ther. 27, 379 (1980); B. von Graffenried, E. Nuesch, Br. J. Clin. Pharmacol. 10, Suppl. 2, 225 (1980). Series of articles on pharmacology, metabolism, analysis, clinical studies, toxicology: Arzneim.-Forsch. 31, 871-940 (1981). Toxicity: G. Rüttimann et al., Arzneim.-Forsch. 31, 882 (1981).
Properties
Crystals, mp 172-174°. LD50 in mice, rats, rabbits (mg/kg): >5000, >3000, 742 orally (Rüttimann).Therapeutic Category
Analgesic.