4199. Flurbiprofen

Nomenclature

CAS number: 5104-49-4
2-Fluoro-α-methyl[1,1′-biphenyl]-4-acetic acid; 2-(2-fluoro-4-biphenylyl)propionic acid; 3-fluoro-4-phenylhydratropic acid; BTS-18322; U-27182; Adfeed (Lead Chem.); Ansaid (Pfizer); Antadys (Théramex); Cebutid (Boots); Froben (Boots); Flurofen (Boots); Ocufen (Allergan); Stayban (Boots); Zepolas (Mikasa).
C15H13FO2; mol wt 244.26.
C 73.76%, H 5.36%, F 7.78%, O 13.10%.

Description and references

Prepn: FR M5737; Adams et al., US 3755427 (1968, 1973 both to Boots Co., Ltd.). Pharmacology: Chalmers et al., Ann. Rheum. Dis. 31, 319 (1972); ibid. 32, 58 (1973); Glenn et al., Agents Actions 3, 210 (1973); Nishizawa et al., Thromb. Res. 3, 577 (1973). HPLC determn in urine and plasma: J. M. Hutzler et al., J. Chromatogr. B 749, 119 (2000). Symposium on pharmacokinetics and clinical efficacy in pain management: Am. J. Med. 80, Suppl. 3A, 1-157 (1986).

Chemical structure

Properties

Crystals from petr ether, mp 110-111°. Slightly sol in water (pH 7.0); readily sol in most polar solvents.

Therapeutic Category

Anti-inflammatory; analgesic.

Keywords

Analgesic; Non-opioids; Acetic/Propionic Acid Derivatives; Anti-inflammatory (Nonsteroidal); Arylpropionic Acid Derivatives