4200. Flurogestone Acetate

Nomenclature

CAS number: 2529-45-5
(11β)-17-(Acetyloxy)-9-fluoro-11-hydroxypregn-4-ene-3,20-dione; 9-fluoro-11β,17-dihydroxypregn-4-ene-3,20-dione-17-acetate; 17α-acetoxy-9α-fluoro-11β-hydroxyprogesterone; 9-fluoro-11β,17-dihydroxyprogesterone 17-acetate; flugestone acetate; SC-9880; Chronogest (Intervet); Cronolone (Searle); Synchronate.
C23H31FO5; mol wt 406.49.
C 67.96%, H 7.69%, F 4.67%, O 19.68%.

Description and references

Prepn: Bergstrom et al., J. Am. Chem. Soc. 81, 4432 (1959); Bergstrom, Dodson; Bergstrom, Nicholson, US 2892851; US 2963498 (1959, 1960 to Searle).

Chemical structure

Properties

Crystals from benzene + petr ether, or ethyl acetate + petr ether, mp 266-269°. [α]D +77.6° (in chloroform). uv max (methanol): 238 nm (ε 17500).
Component of Syncro-Mate.

Therapeutic Category

Progestogen.

Therapeutic Category (Veterinary)

Progestogen. Estrus regulation.

Keywords

Progestogen