4230. Fomocaine

Nomenclature

CAS number: 17692-39-6
4-[3-[4-(Phenoxymethyl)phenyl]propyl]morpholine; 4-[3-(α-phenoxy-p-tolyl)propyl]morpholine; P-652; Erbocain (Heilit).
C20H25NO2; mol wt 311.42.
C 77.14%, H 8.09%, N 4.50%, O 10.28%.

Description and references

Prepn: GB 786128 (1957 to Promonta), C.A. 52, 9225h (1958); H. Oelschlger, Arzneim.-Forsch. 9, 313 (1959). Improved synthesis: eidem, ibid. 27, 1625 (1977). Pharmacology: O. Nieschulz et al., ibid. 8, 539 (1958). Metabolism: H. Blume, H. Oelschlger, ibid. 28, 956 (1978). Bioavailability and local anesthetic effect: H. Oelschlger, D. Rothley, ibid. 29, 693 (1979).

Chemical structure

Properties

Colorless crystals from petr ether, mp 52-53°. bp1.1 238-240°. uv max (ethanol): 220, 269 nm (ε 15820, 1373). LD50 i.v. in mice: 175 mg/kg (Nieschulz).

Therapeutic Category

Anesthetic (local).

Keywords

Anesthetic (Local)