4231. Fonazine

Nomenclature

CAS number: 7456-24-8
10-[2-(Dimethylamino)propyl]-N,N-dimethyl-10H-phenothiazine-2-sulfonamide; 10-(2-dimethylaminopropyl)-3-dimethylsulfamidophenothiazine; 3-dimethylsulfamido-10-(2-dimethylaminopropyl)phenothiazine; dimethothiazine; dimethiotazine; dimetiotazine; RP-8599.
C19H25N3O2S2; mol wt 391.55.
C 58.28%, H 6.44%, N 10.73%, O 8.17%, S 16.38%.

Description and references

Serotonin inhibitor. Prepn: GB 814512 (1959 to Rhne-Poulenc). Pharmacokinetics and distribution in dog and rat: O. R. W. Lewellen, R. Templeton, Adv. Biochem. Psychopharmacol. 9, 213 (1974). Clinical evaluation in spasticity: W. B. Matthews et al., Acta Neurol. Scand. 48, 635 (1972). HPLC determn in plasma: J. Holt et al., Br. J. Clin. Pharmacol. 13, 282 (1982).

Chemical structure

Derivative

Hydrochloride.
C19H25N3O2S2.HCl; mol wt 428.01.
C 53.32%, H 6.12%, N 9.82%, O 7.48%, S 14.98%, Cl 8.28%.

Properties

Crystals, dec 214°.

Derivative

Methanesulfonate.

Nomenclature

CAS number: 7455-39-2
Dimethothiazine mesylate; fonazine mesylate; Banistyl (M & B); Bonpac (Hoei); Calsekin (Mect); Migristène (Specia); Neomestine (Taiyo); Promaquid (Rhne-Poulenc); Yoristen (Kodama).
C19H25N3O2S2.CH3SO3H; mol wt 487.66.
C 49.26%, H 5.99%, N 8.62%, O 16.40%, S 19.73%.

Therapeutic Category

Antimigraine.

Keywords

Antimigraine