4259. Fospropofol

Nomenclature

CAS number: 258516-89-1
1-[2,6-Bis(1-methylethyl)phenoxy]methanol 1-dihydrogen phosphate; phosphono-O-methyl-2,6-diisopropylphenol.
C13H21O5P; mol wt 288.28.
C 54.16%, H 7.34%, O 27.75%, P 10.74%.

Description and references

Prodrug of propofol, q.v. Prepn: V. J. Stella et al., WO 0008033; eidem, US 6204257 (2000, 2001 to Univ. Kansas). Clinical pharmacokinetics and pharmacodynamics: J. Fechner et al., Anesthesiology 99, 303 (2003) DOI PubMed. Clinical evaluation to induce and maintain sedation: eidem, Anesth. Analg. 100, 701 (2005) DOI PubMed. Clinical comparison with propofol: E. Gibiansky et al., Anesthesiology 103, 718 (2005) DOI PubMed; M. M. R. Struys et al., ibid. 730. Clinical trial in moderate sedation in flexible bronchoscopy: G. A. Silvestri et al., Chest 135, 41 (2009) DOI PubMed. Review: M. D. Krasowski, Curr. Opin. Investig. Drugs 6, 90-98 (2005) PubMed.

Chemical structure

Properties

Colorless oil, unstable on standing at room temp.

Derivative

Disodium salt.

Nomenclature

CAS number: 258516-87-9
Fospropofol disodium; GPI-15715; Aquavan (Guilford); Lusedra (Eisai).
C13H19Na2O5P; mol wt 332.24.
C 47.00%, H 5.76%, Na 13.84%, O 24.08%, P 9.32%.

Properties

White powder. Sol in water.

Therapeutic Category

Anesthetic (intravenous).

Keywords

Anesthetic (Intravenous)