4275. Fructose-1,6-diphosphate

Nomenclature

CAS number: 488-69-7
d-Fructose 1,6-bis(dihydrogen phosphate); 1,6-d-fructosediphosphoric acid; hexose diphosphate; Harden-Young ester.
C6H14O12P2; mol wt 340.12.
C 21.19%, H 4.15%, O 56.45%, P 18.21%.

Description and references

Formed from fructose-6-phosphate in the presence of ATP, Mg2+ and the enzyme phosphohexokinase. Prepn from glucose, mannose, fructose, sucrose by the action of yeasts: A. Harden, Alcoholic Fermentation (Longmans, Green & Co., New York, 4th ed., 1932); v. Lebedev, Biochem. Z. 36, 254 (1911); cf DE 292817; DE 293864; DE 301590. Fructose-1,6-diphosphate is reversibly split in the presence of aldolase forming 1-phosphodihydroxyacetone and 3-phosphoglyceraldehyde: Meyerhof et al., Biochem. Z. 286, 301 (1936). Metabolism regulation study: M. E. Kirtley, M. McKay, Mol. Cell. Biochem. 18, 141 (1977).

Chemical structure

Derivative

Sodium salt monohydrate.

Nomenclature

Esafosfina (Foscama).

Therapeutic Category

Roborant; tonic.