4329. Gadoversetamide

Nomenclature

CAS number: 131069-91-5
[8,11-Bis(carboxymethyl)-14-[2-[(2-methoxyethyl)amino]-2-oxoethyl]-6-oxo-2-oxa-5,8,11,14-tetraazahexadecan-16-oato(3)]gadolinium; [N,N″-bis[N-(2-methoxyethyl)-carbamoylmethyl]diethylenetriamine-N,N′,N″-triaceto]gadolinium (III); gadolinium diethylenetriamine pentaacetic acid bis(methyoxyethylamide); Gd-DTPA-BMEA; MP-1177; OptiMARK (Mallinckrodt).
C20H34GdN5O10; mol wt 661.76.
C 36.30%, H 5.18%, Gd 23.76%, N 10.58%, O 24.18%.

Description and references

Nonionic paramagnetic contrast agent. Prepn: R. W. Weber, M. P. Periasamy, WO 9001024; R. W. Weber, US 5130120 (1990, 1992 both to Mallinckrodt); M. Periasamy et al., Invest. Radiol. 26, S217 (1991). Paramagentic profile: K. Adzamli et al., ibid. 34, 410 (1999). Clinical pharmacokinetics: S. K. Swan et al., J. Magn. Reson. Imaging 9, 317 (1999). Clinical study in liver imaging: D. L. Rubin et al., ibid. 240; in CNS imaging: R. I. Grossman et al., Invest. Radiol. 35, 412 (2000).

Chemical structure

Properties

Prepd as 0.5 mmol/ml soln, osmolality (37°) 1110 mOsmol/kg water. Viscosity (cP): 3.1 (20°), 2.0 (37°). d25 1.160. Log P (butanol/water): 1.93. LD50 i.v. in mice: 30.3 mmol/kg (Periasamy).

Therapeutic Category

Diagnostic aid (MRI contrast agent).

Keywords

Diagnostic Aid (MRI Contrast Agent)