4388. Gemfibrozil

Nomenclature

CAS number: 25812-30-0
5-(2,5-Dimethylphenoxy)-2,2-dimethylpentanoic acid; 2,2-dimethyl-5-(2,5-xylyloxy)valeric acid; CI-719; Decrelip (Ferrer); Genlip (Teofarma); Gevilon (Pfizer); Lipozid (Pfizer); Lipur (Pfizer); Lopid (Pfizer).
C15H22O3; mol wt 250.33.
C 71.97%, H 8.86%, O 19.17%.

Description and references

Serum lipid regulating agent. Prepn: P. L. Creger, DE 1925423; eidem, US 3674836 (1969, 1972, both to Parke, Davis). Production: O. P. Goel, US 4126637 (1978 to Warner-Lambert). Pharmacology: A. H. Kissebach et al., Atherosclerosis 24, 199 (1976); M. T. Kahonen et al., ibid. 32, 47 (1979). Series of articles on metabolism, clinical pharmacology, kinetics and toxicology: Proc. R. Soc. Med. 69, Suppl 2, 1-120 (1976). Toxicity data: S. M. Kurtz et al., ibid. 15. Clinical trial in hyperlipidemia: J. E. Lewis et al., Pract. Cardiol. 9, 99 (1983). Clinical reduction of cardiovascular risk in patients with low HDL levels: H. B. Rubins et al., N. Engl. J. Med. 341, 410 (1999).

Chemical structure

Properties

Crystals from hexane, mp 61-63°. bp0.02 158-159°. LD50 in mice, rats (mg/kg): 3162, 4786 orally (Kurtz).

Therapeutic Category

Antilipemic.

Keywords

Antilipemic; Fibrates