4428. Giractide

Nomenclature

CAS number: 24870-04-0
1-Glycine-18-l-argininamide-α(1-18)-corticotropin.
C100H156N34O22S; mol wt 2218.59.
C 54.14%, H 7.09%, N 21.47%, O 15.87%, S 1.45%.

Description and references

Polypeptide corresp to the first 18 amino acid residues in corticotropin, in which the 1-serine is replaced by glycine. Prepn: H. Otsuka et al., Bull. Chem. Soc. Jpn. 43, 196 (1970); of the hexaacetate: eidem, JP 70 19061 (1970 to Shionogi), C.A. 73, 110138r (1970). Adrenocorticotropic potency in man: J. Clin. Endocrinol. Metab. 33, 355 (1971). Fluorometric study: T. Muraki et al., Experientia 32, 1605 (1976). Absorption: M. Hirata et al., Chem. Pharm. Bull. 26, 1061 (1978). Chromatographic studies: S. Terabe et al., J. Chromatogr. 172, 163 (1979); M. Schoeneshoefer, A. Fenner, ibid. 224, 472 (1981).

Chemical structure

Properties

[α]D23.5 51.4 ±1.9° (c = 0.472 in 0.1N acetic acid). uv max (0.1N NaOH): 281, 288 nm (ε 6750, 6490).

Derivative

Hexaacetate salt.

Nomenclature

CAS number: 29365-11-5
S-50022; Acthormon (Shionogi).
C100H156N34O22S.6C2H4O2; mol wt 2578.90.
C 52.16%, H 7.04%, N 18.47%, O 21.09%, S 1.24%.

Therapeutic Category

Adrenocorticotropic hormone.

Keywords

Adrenocorticotropic Hormone