4479. Glybuthiazol(e)

Nomenclature

CAS number: 535-65-9
4-Amino-N-[5-(1,1-dimethylethyl)-1,3,4-thiadiazol-2-yl]benzenesulfonamide; N1-(5-tert-butyl-1,3,4-thiadiazol-2-yl)sulfanilamide; sulfatertiobutylthiadiazole; 2-(p-aminobenzenesulfamido)-5-tertiobutyl-1,3,4-thiadiazole; glybuthizol; RP-2259; Glipasol.
C12H16N4O2S2; mol wt 312.41.
C 46.13%, H 5.16%, N 17.93%, O 10.24%, S 20.53%.

Description and references

Prepn: GB 828963 (1960 to Rhne-Poulenc).

Chemical structure

Properties

Needles from ethanol, mp 221-223°. Sol in ethanol (1.0 g/65 ml); in acetone (1.0 g/15 ml); in DMF (1.0 g/3 ml). Insol in water, ether, benzene. Forms a water-sol Na salt.

Therapeutic Category

Antidiabetic.

Keywords

Antidiabetic; Sulfonylurea Derivatives