4480. Glybuzole

Nomenclature

CAS number: 1492-02-0
N-[5-(1,1-Dimethylethyl)-1,3,4-thiadiazol-2-yl]benzenesulfonamide; N-(5-tert-butyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide; 2-benzenesulfonamido-5-tert-butyl-1,3,4-thiadiazole; desaglybuzole; TH-1395; RP-7891; AN-1324; Gludiase (Bellon).
C12H15N3O2S2; mol wt 297.40.
C 48.46%, H 5.08%, N 14.13%, O 10.76%, S 21.56%.

Description and references

Prepn: Macrae, Drain, GB 822947 (1959 to Smith & Nephew), C.A. 54, 4622h (1960); FR M3389 (1965 to Rhne-Poulenc), C.A. 64, 3553a (1966). Pharmacodynamics: Bargeton et al., Arch. Int. Pharmacodyn. 153, 379 (1965).

Chemical structure

Properties

Needles, mp 163°.

Therapeutic Category

Antidiabetic.

Keywords

Antidiabetic; Sulfonylurea Derivatives