Nomenclature
CAS number: 451-71-8
N-[(Cyclohexylamino)carbonyl]-2,3-dihydro-1
H-indene-5-sulfonamide; 1-cyclohexyl-3-(5-indanylsulfonyl)urea; 1-cyclohexyl-3-(5-hydrindenylsulfonyl)urea; SQ-15860; Subose (BMS).
C
16H
22N
2O
3S; mol wt 322.42.
C 59.60%, H 6.88%, N 8.69%, O 14.89%, S 9.95%.
Description and references
Prepd from hydrindene-5-sulfonamide and cyclohexyl
isocyanate: Hoehn, Breuer, US 3097242 (1963 to Olin Mathieson). Clinical
pharmacology: Grinnell et al., Am. J. Med. Sci. 253, 312 (1967).
Properties
Crystals from 70% acetone, mp 153-155°.Therapeutic Category
Antidiabetic.
Keywords
Antidiabetic; Sulfonylurea Derivatives