4559. Guanadrel

Nomenclature

CAS number: 40580-59-4
(1,4-Dioxaspiro[4.5]dec-2-ylmethyl)guanidine.
C10H19N3O2; mol wt 213.28.
C 56.31%, H 8.98%, N 19.70%, O 15.00%.

Description and references

Orally active postganglionic sympathetic inhibitor. Prepn: W. R. Hardie, J. E. Aaron, ZA 6706328; eidem, US 3547951 (1968, 1970 both to Cutter). Antihypertensive activity: L. Hansson et al., Clin. Pharmacol. Ther. 14, 204 (1973). In vitro adrenergic neuron blocking activity: L. Roller, Aust. J. Pharm. Sci. 5, 35 (1976). Pharmacologic study: E. M. Johnson, F. E. Hunter, Biochem. Pharmacol. 28, 1525 (1979). Effect on patients with thyrotoxicosis: S. Rubenfeld et al., Arch. Intern. Med. 138, 1106 (1978). Review of pharmacology and efficacy in hypertension: F. A. Finnerty Jr., R. N. Brogden, Drugs 30, 22-31 (1985).

Chemical structure

Derivative

Sulfate.

Nomenclature

CAS number: 22195-34-2
CL-1388R; U-28288D; Hylorel (Aventis).
(C10H19N3O2)2.H2SO4; mol wt 524.63.
C 45.79%, H 7.68%, N 16.02%, O 24.40%, S 6.11%.

Properties

Cryst from methanol/ethanol, mp 213.5-215°.

Therapeutic Category

Antihypertensive.

Keywords

Antihypertensive; Guanidine Derivatives