4567. Guanoxabenz

Nomenclature

CAS number: 24047-25-4
2-[(2,6-Dichlorophenyl)methylene]-N-hydroxyhydrazinecarboximidamide; 1-[(2,6-dichlorobenzylidene)amino]-3-hydroxyguanidine; Compd 43-663.
C8H8Cl2N4O; mol wt 247.08.
C 38.89%, H 3.26%, Cl 28.70%, N 22.68%, O 6.48%.

Description and references

Prepn: W. J. Houlihan, R. E. Manning, DE 1902449; eidem, US 3591636 (1969, 1971 both to Sandoz). Pharmacological study: J. C. Doxey, A. S. Hersom, Br. J. Pharmacol. 70, 171 (1980).

Chemical structure

Derivative

Hydrochloride.

Nomenclature

CAS number: 23256-40-8
Benzerial (Houdé).
C8H8Cl2N4O.HCl; mol wt 283.54.
C 33.89%, H 3.20%, Cl 37.51%, N 19.76%, O 5.64%.

Properties

Crystals from ethanol/ether, mp 173-175°.

Therapeutic Category

Antihypertensive.

Keywords

Antihypertensive; Guanidine Derivatives