4594. Halofantrine

Nomenclature

CAS number: 69756-53-2
1,3-Dichloro-α-[2-(dibutylamino)ethyl]-6-(trifluoromethyl)-9-phenanthrenemethanol; 1-(1,3-dichloro-6-trifluoromethyl-9-phenanthryl)-3-di(n-butyl)aminopropanol; γ-(dibutylamino)-1,3-dichloro-6-(trifluoromethyl)-9-phenanthrenepropanol.
C26H30Cl2F3NO; mol wt 500.42.
C 62.40%, H 6.04%, Cl 14.17%, F 11.39%, N 2.80%, O 3.20%.

Description and references

Prepn of the hydrochloride: W. T. Colwell et al., J. Med. Chem. 15, 771 (1972); of the β-glycerophosphate salt: J. F. Rossignol, EP 138374; idem, US 4507288 (both 1985 to Smithkline Beckman). Antimalarial activity in vivo: L. H. Schmidt et al., Antimicrob. Agents Chemother. 14, 292 (1978). HPLC determn in human blood: J. W. Hines et al., J. Pharm. Sci. 74, 433 (1985). Antimalarial activity in clinically-induced infection in humans: J. Rinehart et al., Am. J. Trop. Med. Hyg. 25, 769 (1976); T. M. Cosgriff et al., ibid. 31, 1075 (1982); in naturally acquired disease: J. P. Coulaud et al., Trans. R. Soc. Trop. Med. Hyg. 80, 615 (1986). Review of pharmacology and therapeutic potential: H. M. Bryson, K. L. Goa, Drugs 43, 236-258 (1992).

Chemical structure

Derivative

Hydrochloride.

Nomenclature

CAS number: 36167-63-2
SKF-102886; WR-171669; Halfan (SKB).
C26H30Cl2F3NO.HCl; mol wt 536.88.
C 58.17%, H 5.82%, Cl 19.81%, F 10.62%, N 2.61%, O 2.98%.

Properties

Two crystalline forms have been reported: mp 93-96°, mp 203-204°.

Derivative

β-Glycerophosphate.
C29H39Cl2F3NO7P; mol wt 672.50.
C 51.79%, H 5.85%, Cl 10.54%, F 8.48%, N 2.08%, O 16.65%, P 4.61%.

Properties

White crystals, mp 60-65°.

Therapeutic Category

Antimalarial.

Keywords

Antimalarial