4593. Halobetasol Propionate

Nomenclature

CAS number: 66852-54-8
(6α,11β,16β)-21-Chloro-6,9-difluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)pregna-1,4-diene-3,20-dione; 21-chloro-6α,9-difluoro-11β,17-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17-propionate; ulobetasol propionate; BMY-30056; CGP-14458; Ultravate (BMS).
C25H31ClF2O5; mol wt 484.96.
C 61.92%, H 6.44%, Cl 7.31%, F 7.84%, O 16.50%.

Description and references

Trihalogenated corticosteroid structurally related to clobetasol, q.v. Prepn: J. Kalvoda, G. Anner, DE 2743069; eidem, US 4619921 (1978, 1986 both to Ciba-Geigy). Clinical pharmacology in psoriatic patients: W. A. Watson et al., Pharmacotherapy 10, 107 (1990). Clinical trial in localized vitiligo: L. Xunquan et al., Int. J. Dermatol. 29, 295 (1990).

Chemical structure

Properties

Crystals from methylene chloride/ether, mp 220-221°.

Therapeutic Category

Anti-inflammatory.

Keywords

Glucocorticoid