Description and references

A starch derivative of undetermined exact composition. Comprised of more than 90% amylopectin and etherified to the extent that an average of 7 to 8 of the OH groups present in every ten d-glucopyranose units of the polymer have been converted to OCH₂CH₂OH groups. Preparation by treating starch with pyridine and ethylene chlorohydrin: Mima, Yokoyama, JP 70 6556 (1970 to Green Cross), C.A. 73, 36822r (1970). Structure evaluation studies: Banks et al., Br. J. Pharmacol. 47, 172 (1973). Physicochemical and biological properties: Tamada et al., Chem. Pharm. Bull. 19, 286 (1971); Banks et al., Staerke 24, 181 (1972). Pharmacology: Irikura et al., Oyo Yakuri 6, 985 sqq (1972). Metabolism: Bogan et al., Toxicol. Appl. Pharmacol. 15, 206 (1969); Ryan et al., Xenobiotica 2, 141 (1972). Toxicity studies: Irikura et al., Oyo Yakuri 6, 1023 (1972). Introduction as a plasma expander: Wiedersheim, Arch. Int. Pharmacodyn. 111, 353 (1957). Review of production and uses: Hjermstad, Starch Chem. Technol. 2, 423-432 (1967).

Properties

Derivative