Nomenclature
CAS number: 118-74-1
Perchlorobenzene; Anticarie; Bunt-cure; Bunt-no-more; Julin's carbon chloride.
C
6Cl
6; mol wt 284.78.
C 25.31%, Cl 74.70%.
Description and references
Prepn: Becke, Sperber, US 2792434 (1957 to BASF). Teratogenicity
study: K. D. Courtney et al., Toxicol. Appl. Pharmacol. 35, 239 (1976).
Carcinogenicity studies: J. R. P. Cabral et al., Nature 269, 510 (1977); D. L.
Arnold et al., Food Chem. Toxicol. 23, 779 (1985) (corr. ibid. 26, 169 (1988)). uv spectrum: H. Conrad-Billroth, Z. Phys. Chem. 19, 76 (1932);
O. Schnepp, R. Kopelman, J. Chem. Phys. 30, 868 (1959). Toxicology: G. Vettorazzi, Residue Rev. 56, 107 (1975); R.
Ockner, R. Schmid, Nature 189, 499 (1961). Review of toxicology and human exposure:
Toxicological Profile for Hexachlorobenzene (PB2003-100139, 2002) 403 pp.
Properties
Needles. d23 2.044. mp 231°. bp 323-326°. Vapor pressure at 20°: 1.09 × 105 mm Hg. Poisonous. Sublimable. Insol in water.
Sparingly sol in cold alcohol; sol in benzene, chloroform, ether.
Flash point 242°C.Note
Not to be confused with benzene hexachloride,
see Lindane.
Caution
Potential symptoms of chronic oral
overexposure are dermal lesions, hypertrichosis, anorexia, weight
loss, focal alopecia, corneal opacity, atrophic hands, hepatomegaly,
porphyria, skeletal muscle wasting. See Clinical Toxicology of Commercial Products, R. E. Gosselin et al., Eds. (Williams & Wilkins,
Baltimore, 5th ed., 1984) Section II, pp 170-171; Patty's Industrial Hygiene and Toxicology vol. 2B, G. D. Clayton, F. E. Clayton, Eds. (John Wiley & Sons, New York,
4th ed., 1994) pp 1477-1492. This substance is reasonably anticipated
to be a human carcinogen: Report on Carcinogens,
Eleventh Edition (PB2005-104914, 2004) p III-138.Use
In organic syntheses. Formerly as agricultural
fungicide.