4693. Hexaminolevulinate
Nomenclature
CAS number: 140898-97-1
5-Amino-4-oxopentanoic acid hexyl ester; 5-aminolevulinic acid hexyl ester; hexyl 5-aminolevulinate. C11H21NO3; mol wt 215.29.
C 61.37%, H 9.83%, N 6.51%, O 22.29%.
Description and references
Prodrug of δ-aminolevulinic acid, q.v.; induces production of intracellular protoporphyrin IX. Prepn: H. Takeya, JP Kokai 92 9360 (1992 to Cosmo Sogo Kenkyusho); and use as photosensitizer: K. E. Gierskcky et al., WO 9628412 (1996 to Norwegian Radium Res. Found.); eidem, US 6034267 (2000 to PhotoCure). Synthesis and pharmacology: C. J. Whitaker et al., Anti-Cancer Drug Des. 15, 161 (2000). Clinical evaluation for photodetection of bladder cancer: N. Lange et al., Br. J. Cancer 80, 185 (1999).
Derivative
Hydrochloride.Nomenclature
CAS number: 140898-91-5
P-1206; Hexvix (PhotoCure). C11H21NO3.HCl; mol wt 251.75.
C 52.48%, H 8.81%, N 5.56%, O 19.07%, Cl 14.08%.
Properties
Crystals from methanol/ethyl acetate, mp 94°.Therapeutic Category
Diagnostic aid (fluorescence imaging agent).
Keywords
Diagnostic Aid