4694. n-Hexane

Nomenclature

CAS number: 110-54-3
Hexane.
C6H14; mol wt 86.18.
C 83.62%, H 16.37%.

Description and references

Chief constituent of petr ether, ligroin, and commercial hexane. Review of toxicity and metabolism: D. Couri, M. Milk, Annu. Rev. Pharmacol. Toxicol. 22, 145-166 (1982). Book: Technology and Solvents for Extracting Oilseeds and Nonpetroleum Oil, P. J. Wan, P. J. Wakelyn, Eds. (AOCS Press, Champaign, 1987) 350 pp.

Chemical structure

Properties

Colorless, very volatile liquid; faint, peculiar odor. d420 0.6591. bp 69°. mp 100 to 95°. nD20 1.375. Flash point: 18.0°C. Vapor pressure (mmHg): 186.1 at 30°, 400.6 at 50°. Partition coefficient (1-octanol/water) at 25°: >4100. Spec heat at 22.0°: 0.536 cal/g/°C. Viscosity at 15°: 0.337 cP. Heat of vaporization: 79.4 cal/g. Surface tension at 20°: 18.41 dyne/cm. Insol in water. Miscible with alcohol, chloroform, ether. LC50 (4 hr) in mice by inhalation: 48000 ppm; LD50 orally in rats: 32.0 g/kg (Couri, Milks).

Caution

Potential symptoms of overexposure are lightheadedness; giddiness; nausea, headache; peripheral neuropathy; numbness of extremities, muscle weakness; irritation of eyes and nose; dermatitis; aspiration of liquid may cause chemical pneumonia. See NIOSH Pocket Guide to Chemical Hazards (DHHS/NIOSH 97-140, 1997) p 162.

Use

Determining refractive index of minerals. Filling for thermometers instead of mercury, usually with a blue or red dye. Extraction solvent for oilseed processing. Organic solvent for high performance liquid chromatography.